R10065 |
Losartan potassium |
Losartan is an angiotensin II receptor antagonist, competes with the binding of
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R10066 |
Dapagliflozin; BMS512148 |
Dapagliflozin (BMS-512148) 是一种用于治疗糖尿病 (DM) 的新型药物,是一种竞争性葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可导
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R10068 |
GSK1120212; Trametinib; JTP74057 |
曲美替尼 Trametinib (GSK1120212;JTP-74057) 是有效的 MEK 抑制剂,抑制 MEK1 和 MEK2 的 IC50 约为 2 n
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R10071 |
SRT1720 HCl |
SRT1720 HCl是一种选择性的SIRT1激活剂,无细胞试验中EC50为0.16 μM,对SIRT2和SIRT3的作用弱230倍以上。
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R10072 |
GSK690693 |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM
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R10073 |
Apitolisib (Synonyms: GDC-0980; GNE 390; RG 7422) |
Apitolisib (GDC-0980; GNE 390; RG 7422) 是一种口服有效的 PI3K 和 mTOR (TORC1/2) 激酶抑制剂,抑制
|
R10074 |
AZ628 |
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 1
|
R10075 |
Apalutamide (ARN-509) |
Apalutamide (ARN-509) 是有效,竞争性的 雄激素受体 (AR) 拮抗剂,IC50 为 16 nM。
|
R10076 |
Crizotinib (PF-02341066) |
Crizotinib (PF-02341066) 是一种口服生物可用的,具有选择性的 ATP 竞争性双 ALK 和 c-Met 抑制剂,IC50 分别为 20
|
R10077 |
AMG208 |
AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.
|
R10078 |
EMD1214063 |
Tepotinib (EMD 1214063) is a potent and selective c-Met inhibitor with IC50 of 4
|
R10079 |
GSK2636771 |
GSK2636771是有效,选择性和可口服的 PI3Kβ 抑制剂,Ki和IC50分别为0.89,5.2 nM,比p110α和p110γ的选择性高900倍,比p1
|
R10080 |
TH-302 |
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid
|
R10081 |
TAS103 dihydrochloride |
TAS-103 2Hcl(BMS-247615 2Hcl) is a dual inhibitor of topoisomerase-I (topo-I) an
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R10082 |
Palomid 529; P529 |
Palomid 529 是一种有效的 mTORC1 和 mTORC2 复合体抑制剂。
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R10083 |
XL413 Hydrochloride |
XL413 hydrochloride 是一种有效的,选择性的,ATP 竞争性的 Cdc7 抑制剂,IC50 值为 3.4 nM,同时对 CK2 和 PIM1
|
R10084 |
Orteronel; TAK-700 |
Orteronel(TAK-700) was selected as a candidate for clinical evaluation. orterone
|
R10085 |
KU-55933 |
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50
|
R10086 |
BAY571293 |
Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting anti
|
R10087 |
AZD9291 |
Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibi
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R10088 |
RTA408; Omaveloxolone |
RTA-408 是一种抗氧化炎症调节剂 (AIM),可激活 Nrf2 并抑制一氧化氮 (NO)。RTA-408 通过抑制 STING 依赖的
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R10090 |
AZD5438 |
AZD-5438 是有效的 CDK1/2/9 抑制剂,IC50 值分别为 16 nM/6 nM/20 nM;对GSK3β,CDK5,CDK6的抑制作用较弱。&n
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R10091 |
LCZ696;Sacubitril;Valsartan |
Varespladib (LY315920) 是一种有效且具有选择性的 group IIA, secretory phospholipase A2 (sPLA2
|
R10092 |
TWS11 |
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of
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R10093 |
VU0364439 |
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
|