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  • GSK1349572 sodiuM salt(Dolutegravir sodium)

    GSK1349572 sodiuM salt(Dolutegravir sodium)

    R11551
    Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H,
  • Sugammadex

    Sugammadex

    R11459
    Sugammadex (Org 25969, tradename Bridion) is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA).
  • Eliglustat (Tartrate)

    Eliglustat (Tartrate)

    R11057
    Eliglustat tartrate (Genz-112638), a specific inhibitor of glucosylceramide synthase, is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1).
  • GS-7340 hemifumarate

    GS-7340 hemifumarate

    R10962
    GS-7340 (Tenofovir alafenamide) hemifumarate is an investigational oral prodrug of the HIV-1 nucleotide reverse transcriptase inhibitor Tenofovir (TFV).
  • ozanimod

    ozanimod

    R10950
    Ozanimod is a novel, oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerativ
  • Mianserin hydrochloride

    Mianserin hydrochloride

    R10466
    Mianserin is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.
  • AST-1306 TsOH

    AST-1306 TsOH

    R10006
    AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective f
  • R406 Free base

    R406 Free base

    R10002
    R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.
  • R788; Fostamatinib

    R788; Fostamatinib

    R10001
    Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
  • GS7340

    GS7340

    R10583
    Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
  • AKT inhibitor VIII (AKTI-1/2)

    AKT inhibitor VIII (AKTI-1/2)

    R10014
    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 M for Akt1, Akt2, and Akt3, respect
  • PF04691502

    PF04691502

    R10013
    PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK,
  • AT-406

    AT-406

    R10005
    AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins,
  • VX-809; Lumacaftor

    VX-809; Lumacaftor

    R10004
    VX-809 (Lumacaftor) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.