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目录号 产品名称 产品描述
R10007 AZD6244 Selumetinib (AZD6244) is a potent, highly selective MEK1 inhibitor with IC50 of
R10031 BIIB-024; MLN2480 MLN2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in chinical tri
R10068 GSK1120212; Trametinib; JTP74057 曲美替尼 Trametinib (GSK1120212;JTP-74057) 是有效的 MEK 抑制剂,抑制 MEK1 和 MEK2 的 IC50 约为 2 n
R10074 AZ628 AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 1
R10135 GDC0879 GDC-0879 is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM
R10190 BIX02188 BIX02188 是一种有效的选择性 MEK5 抑制剂,IC50 为 4.3 nM。 BIX02188 也选择性抑制 ERK5 活性, IC50 为 810 n
R10216 PLX4032 Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with
R10226 PLX4720 PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in
R10250 TAK632 TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(w
R10412 Vemurafenib (PLX4032, RG7204) Vemurafenib (PLX4032, RG7204)是一种新型有效的B-RafV600E抑制剂,IC50为31 nM。Vemurafenib对B-RafV
R10680 ZM336372 ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold
R10829 SCH772984 SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM in
R10934 BI-847325 BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibi
R10942 Binimetinib; MEK162,ARRY-162,ARRY-438162 Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with
R10952 GDC-0973 ; XL-518 Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor w
R11503 Dabrafenib (GSK2118436) Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8
R11507 bms582949 BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 M
R11583 GDC-0994 GDC-0994 is a potent, orally available ERK1/2 inhibitor with IC50 of 1.1 nM and
R11586 DEL-22379 DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.
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