R10030 |
MLN4924 |
MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) i
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R10031 |
BIIB-024; MLN2480 |
MLN2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in chinical tri
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R10032 |
SLx-2119 (KD-025) |
SLx-2119 (KD-025) 是选择性的 ROCK2 抑制剂,IC50 值为 105 nM。
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R10033 |
MLN8237 |
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a c
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R10034 |
MK8745; MK-8745 |
MK-8745是极光激酶抑制剂 (aurora A),IC50 值为0.6 nM。
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R10035 |
MDL28170 |
MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent
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R10036 |
XL880; Foretinib; GSK136308 |
Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly
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R10037 |
ANA12 |
ANA-12是有效,选择性的 TrkB 拮抗剂,对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM。
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R10038 |
CX-4945 |
CX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinas
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R10040 |
IP-145; Duvelisib; INK1197 |
Duvelisib 是一种选择性 p100δ 抑制剂,作用于 p110δ, p110γ, p110β 和 p110α,IC50 分别为 2.5 nM,27.4
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R10041 |
Vesnarinone (OPC-8212) |
Vesnarinone是一种喹啉酮衍生物, 药效学效应包括抑制磷酸二酯酶III (PDE3) 活性,增加钙通量, 及减小钾通量。
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R10042 |
CO1686; Rociletinib |
Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibit
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R10044 |
WZ4003 |
WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM
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R10045 |
Fluoroclebopride |
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R10046 |
TORIN1 |
Torin 1 是一种有效的 mTOR 抑制剂,IC50 为 3 nM。Torin 1 抑制 mTORC1/2 复合物,IC50 值在 2 和 10 nM 之间
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R10047 |
Vortioxetine |
Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5
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R10048 |
Temsavir; BMS-626529 |
BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp1
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R10049 |
TP-808;TP808 |
TP808是影响多种四环素抗生素合成的关键中间体。
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R10054 |
TAE684 |
TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor with IC50 of 3 nM in
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R10056 |
Tubastatin-A |
Tubastatin A is a potent and selective HDAC6 inhibitor withIC50 of 15 nM in a ce
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R10058 |
Masitinib |
Masitinib is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540
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R10060 |
Nadifloxacin; Acuatim; Nadixa; OPC7251 |
Nadifloxacin is a topical fluoroquinolone antibiotic for the treatment of acne v
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R10061 |
Nexavar; Bay 43-9006; Sorafenib |
Sorafenib Tosylate is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with I
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R10062 |
SAR131675 |
SAR131675是一种VEGFR3抑制剂,无细胞试验中IC50/Ki为23 nM/12 nM,作用于VEGFR3比作用于VEGFR1/2选择性高50和10倍,
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R10064 |
Brivanib; BMS540215 |
Brivanib 是一种ATP竞争性的 VEGFR2 抑制剂,IC50 值为 25 nM;可以适度抑制 VEGFR-1 和 FGFR-1,对 VEGFR2 的选
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