BKM-120;BKM120; BKM 120; NVP-BKM120

CAS NO.:1202777-78-3

分子式:C₁₈H₂₁F₃N₆O₂

分子量:410.39

纯度: > 98%

溶解性: (R.T.: 25℃): DMSO

稳定性: - 20℃ 3 years

BKM120 (NVP-BKM120) is a novel phosphatidylinositol 3-kinase (PI3K) inhibitor and is currently being investigated in phase I clinical trials in solid tumors. Unlike other inhibitors, it does not inhibit the related kinases-mTOR and Vps34. BKM120 (NVP-BKM120) has shown significant cell growth inhibition and induction of apoptosis in a variety of tumor cell lines as well as in animal models, it decreases the cellular levels of p-Akt in mechanistic models and relevant tumor cell lines.

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