Emedastine

CAS NO.:87233-61-2

分子式:C₁₇H₂₆N₄O

分子量:302.41

纯度: > 98%

溶解性: (R.T.: 25℃): DMSO

稳定性: - 20℃ 3 years

Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.

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当前批次纯度大于98%，产品COA和相关检测报告可提供电子版或随货发出；
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