MELK-T1(JNJ-47117096)

CAS NO.:1610586-62-3

分子式:C₂₁H₂₂N₄O₂

分子量:362.424984455109

纯度: > 98%

溶解性: (R.T.: 25℃): DMSO

稳定性: - 20℃ 3 years

MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells. MELK-T1 triggered a rapid and proteasome-dependent degradation of the MELK protein. Treatment of MCF-7 breast adenocarcinoma cells with MELK-T1 induced the accumulation of stalled replication forks and double-strand breaks that culminated in a replicative senescence phenotype. MELK-T1 induced a strong phosphorylation of p53, a prolonged upregulation of p21 and a downregulation of FOXM1 target genes.

可提供多种规格，大量可定制；

如需更多规格的报价，请点击询价或者通过在线QQ及电子邮件联系！

当前批次纯度大于98%，产品COA和相关检测报告可提供电子版或随货发出；
所有可选规格：常温运输或根据产品特性加蓝冰运输。
本公司所有产品仅供实验科研使用，不为任何个人提供产品和服务。