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AP24534; AP-24534; AP 24534; Ponatinib HCl; Ponatinib hydrochloride
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详细信息:
理论数据
CAS NO.:1114544-31-8
分子式:C29H28ClF3N6O
分子量:569.02
纯度: > 98%
溶解性: (R.T.: 25℃): DMSO
稳定性: - 20℃ 3 years
简述
ponatinib, also known as AP24534 is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors. Ponatinib was approved in 2012.
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